A large class of glycoproteins similar to lymphokines but produced by non-lymphocytic cells such as normal macrophages, fibroblasts, keratinocytes and a variety of transformed cell lines. The most well known cytokines are the interferon (IFN) and interleukins (IL-1, IL-6). They were discovered through their role in regulating immunological and inflammatory and repair processes. However, they also regulate normal cell growth and differentiation.
Cytokines are analagous to hormones in their intercellular regulatory functions at very low concentrations, but are not produced by glands. [see Endocrinology]
Hence, some discovered by their action, rather than their chemical structure, have been named Growth_Factors, and yet these function throughout life, eg. to stimulate the endothelial cells to express 'selectins' on the internal surfaces of blood vessels, causing leukocytes to adhere, then be removed from circulation between endothelial cells.
Subscription and submission invitation for articles on study and applications of interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, and putative cytokines in the official journal of the International Cytokine Society, published by Academic Press.
Mood and cognitive disorders in cancer patients receiving cytokine therapy. Abstract.
Abstract of review of recent developments in cytokine biology that are relevant to clinical psychiatry. The role of cytokines in various brain activities and pathophysiology of specific psychiatric disorders.
Cytokines and their role in the development of chronic inflammation in asthma
COPE, claiming over 45,000 entries, over 100,000 references on cytokine research, hyperlinks, with tables, formulae, graphics, and integrated sub-dictionaries on related disciplines. Includes profile of author Prof. Horst Ibelgaufts.
Arachidonic acid metabolic pathways. Synthesis of prostanoids, lipoxin and leukotriene.
Overview of regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action.
The cytokine-interferon open forum, downloadable PDF newsletters, links to conferences, meetings, related websites and journals as well as society matters and membership details along with application forms.
Information and links about nerve growth factors.
Cytokines mini-reviews, their applications, cytokine facts and literature, maintained by R&D Systems company.
Promoting collaboration and outsourcing to develop cell culture processes, including proliferation and neutralization bioassays, using their cytokines and growth factors in cell culture media, from manufacturer at Natick, MA.
Provides membership details, conference calendar, newsletters and resources.
Thanks to DMOZ, which built a great web directory for nearly two decades and freely shared it with the web. About us